Conditional β1‐integrin‐deficient mice display impaired pancreatic β cell function

摘要: β1-Integrin, a critical regulator of β cell survival and function, has been shown to protect against death promote insulin expression secretion in rat human islet cells vitro. The aim the present study was examine whether knockout β1-integrin collagen I-producing would have physiological functional implications pancreatic endocrine vivo. Using adult mice with conditional cells, effects deficiency on glucose metabolism were examined. Male β1-integrin-deficient display impaired tolerance, significant reduction content (p < 0.01). Morphometric analysis revealed mass 0.001) mice, along decrease proliferation, Pdx-1 Nkx6.1 when compared controls. Interestingly, these morphometric alterations female less significant. Furthermore, displayed decreased FAK 0.05) ERK1/2 phosphorylation, reduced cyclin D1 levels increased caspase 3 cleavage 0.01), while no changes Akt phosphorylation observed, indicating that signals through FAK-MAPK-ERK pathway Our results demonstrate is involved regulation contributes maintenance function