Jak kinases and regulation of cytokine signal transduction
作者： Bruce A. Witthuhn , Ollie Silvennoinen , Frederick W. Quelle , James N. Ihle
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摘要: Provided are methods for regulating the cellular response to cytokines by inhibiting or enhancing of at least one Jak kinase activity which mediates response; assays identifying inhibitors cytokine-induced activation useful in invention also provided; antibodies raised against peptide fragments epitope specific a without interfering with activity; polypeptides kinases; and nucleic acid encoding therefor.
lens.org参考文章(89)
Stephen M. Edgington, Molecular crosstalk. Will virology and growth-factor research aid cytokine drug discovery? Nature Biotechnology. ,vol. 11, pp. 465- 470 ,(1993) , 10.1038/NBT0493-465
Krolewski Jj, Byers M, Firmbach-Kraft I, Dalla-Favera R, Shows T, tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. Oncogene. ,vol. 5, pp. 1329- 1336 ,(1990)
CJ Sanderson, Interleukin-5, Eosinophils, and Disease Blood. ,vol. 79, pp. 3101- 3109 ,(1992) , 10.1182/BLOOD.V79.12.3101.3101
S G Rane, E P Reddy, JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells. Oncogene. ,vol. 9, pp. 2415- 2423 ,(1994)
T Torigoe, R O'Connor, D Santoli, JC Reed, Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines Blood. ,vol. 80, pp. 617- 624 ,(1992) , 10.1182/BLOOD.V80.3.617.617
A F Wilks, A Ziemiecki, A C Andres, R R Aston, A G Harpur, JAK2, a third member of the JAK family of protein tyrosine kinases. Oncogene. ,vol. 7, pp. 1347- 1353 ,(1992)
J L Cleveland, M Dean, N Rosenberg, J Y Wang, U R Rapp, Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl. Molecular and Cellular Biology. ,vol. 9, pp. 5685- 5695 ,(1989) , 10.1128/MCB.9.12.5685
David E. Kennell, Principles and practices of nucleic acid hybridization. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 11, pp. 259- 301 ,(1971) , 10.1016/S0079-6603(08)60330-X
Andrew Fwilks, Cloning members of protein-tyrosine kinase family using polymerase chain reaction. Methods in Enzymology. ,vol. 200, pp. 533- 546 ,(1991) , 10.1016/0076-6879(91)00169-W
J. Thomas Ngo, Joe Marks, Martin Karplus, Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox The Protein Folding Problem and Tertiary Structure Prediction. pp. 433- 506 ,(1994) , 10.1007/978-1-4684-6831-1_14