Lung function in young adults with congenital diaphragmatic hernia; a longitudinal evaluation.

摘要: Background Survival rates of patients with congenital diaphragmatic hernia (CDH) have improved to up 80%. Little is known about long-term consequences the disease and its treatment. We evaluated lung function respiratory symptoms longitudinally in a previously studied cohort CDH age-matched non-CDH who underwent similar neonatal intensive care treatment. Study Design We tested 27 young adults [mean (SD) age: 26.8 years (2.9)] 30 patients. Dynamic static volumes, midexpiratory flows, diffusion capacity were expressed as mean standard deviation scores. Prevalence was European Community Respiratory Health Survey. Results All data are (SD). FEF25–75 had slightly deteriorated since childhood (CDH: −0.7 (1.4) vs. −1.6 (1.5), P < 0.001; patients: 0.2 −0.3 (1.6), P = 0.038, ns). Diffusion decreased both groups DLCOc (1.1) −1.5 (1.1), P <0.001; non-CDH: 0.1 (0.4) −1.1 P < 0.001). Lung volumes normal groups. The prevalence asthma higher than population (27.6% 30% controls, P < 0.001). Conclusions Airflow obstruction mildly from into adulthood survivors CDH. survival more severe forms calls for follow-up function. Pediatr Pulmonol. 2013; 48:130–137. © 2012 Wiley Periodicals, Inc.