Supratentorial malignant glioma: an analysis of radiation therapy in 178 cases.

摘要: Abstract To analyze treatment results of supratentorial malignant gliomas in the megavoltage era, all histologic specimens were reviewed and glioblastoma multiforme (GBM) was distinguished from anaplastic astrocytoma (AA) by presence necrosis. Among those who had completed radiotherapy been followed for at least one year, 135 GBM 43 AA patients found. The median survival time (MST) after operation 12 months 18 AA. 5-year rate 0.9% 18% size radiation field little influence on time; MST treated with a local covering tumor plus less than 2 cm margin, generous (2 or more margin), 13 to whole brain. Also AA, brain did not prolong survival. Initial relapse developed within irradiated volume 86% cases field. Whole seemed useless gliomas. Survival appeared be dose-dependent; 10, 13, 16 received 45–57, 57–63, 63–72 Gy, respectively. Extensive surgical resection associated better prognosis GBM. 60 years old older poorer younger patients, but age significant prognostic factor Chemotherapy slightly without improving long-term Currently, an accelerated hyperfractionation regimen is being tested which 1.5 Gy given twice day up 69 Gy. Preliminarily, this no acute late toxicity yielded equivalent conventional regimen.