Rosemary-stimulated reduction of DNA strand breaks and FPG-sensitive sites in mammalian cells treated with H2O2 or visible light-excited Methylene Blue
作者： Darina Slameňová , Katarı́na Kubošková , Eva Horváthová , Soňa Robichová
DOI: 10.1016/S0304-3835(01)00784-4
关键词:
摘要: Abstract In this study possible protective effects of rosemary against oxidative DNA damage induced by H 2 O - and visible light-excited Methylene Blue in colon cancer cells CaCo-2 hamster lung V79 were investigated. The level (DNA strand breaks) was measured using the classical modified single cell gel electrophoresis, so-called comet assay. Our findings showed that an ethanol extract from reduced genotoxic activity both agents after a long-term (24 h; 0.3 μg/ml) or short-term (2 30 pre-incubation cells. We suggest exhibits effect to as consequence scavenging OH radicals singlet oxygen ( 1 ).
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