Comparison of 13 Acellular Pertussis Vaccines: Adverse Reactions

摘要: Objective. To compare the reactogenicity of a licensed conventional whole-cell (WCL) and 13 acellular pertussis vaccines that differed in source, manufacture, quantity included antigens; all diphtheria tetanus toxoids. Methods. Healthy infants were enrolled through six university-based vaccine treatment evaluation units randomized to receive one study at 2, 4, 6 months age. Parents recorded occurrence fever, redness, swelling, pain, fussiness, drowsiness, anorexia, use antipyretics for 2 weeks after each inoculation; nurses interviewed parents on third day succeeding visit; long-term follow-up information was collected from medical records 1 year immunization. Results. Of 2200 vaccinated infants, 2189 contributed reaction data 6375 vaccinations. For every vaccine, monitored except vomiting occurred significantly lower frequency severity than seen with WCL. The groups receiving respect vomiting, but not antipyretic use, or anorexia. Conclusion. Although there differences among vaccines, none consistently most least reactogenic; associated substantially fewer less severe adverse reactions standard commercial vaccine. Selection further development introduction into efficacy trials can give priority assessments immunogenicity purity, comparative secondary consideration.