Association of interleukin‑6 (‑174 G/C) polymorphism with the prostate cancer risk: A meta‑analysis

摘要: The aim of the present study was to determine whether interleukin-6 (IL-6) (-174 G/C) gene polymorphism correlates with prostate cancer. A meta-analysis based on former studies conducted and results suggest that there no significant association between IL-6 cancer risk. However, a recent published in January 2014 showed GG genotype may be associated an increased risk Caucasian subjects, whereas CC African-American which inconsistent studies. Databases, including PubMed, Embase, Web Science, Cochrane Library, Chinese Biomedical Literature Database Wanfang database, were searched 1994 March eligible susceptibility total 11 10,745 cases 13,473 controls fulfilled inclusion criteria subsequent assessment by two investigators. pooled odds ratio (OR) 95% confidence interval (95% CI) calculated examine associations, subgroup analyses performed according ethnicity. Overall, found risk, analysis suggested slightly under homozygote (CC vs. GG: OR, 3.43; CI, 1.01–11.71; P=0.049) recessive models GG/GC: 3.51; 1.04–11.82; P=0.042) patients. Caucasian, Asian or mixed populations five genetic stratifying for In conclusion, patients,