Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes
作者： S.W. Whiteheart , M Brunner , D.W. Wilson , M Wiedmann , J.E. Rothman
DOI: 10.1016/S0021-9258(19)49830-X
关键词:
摘要: Abstract Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) are required for the binding of protein (NSF) to Golgi membranes and are, therefore, intra-Golgi transport. We report existence distinct alpha/beta-SNAP gamma-SNAP-binding sites in that appear be part same receptor complex. Cross-linking studies with alpha-SNAP demonstrate an integral membrane between 30-40 kDa is component multi-SNAP These data suggest SNAPs function by independently a membrane-receptor complex, thereby activating them serve as adaptors targeting NSF.
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