Genetic variants affecting incretin sensitivity and incretin secretion
作者： K. Müssig , H. Staiger , F. Machicao , H.-U. Häring , A. Fritsche
DOI: 10.1007/S00125-010-1876-8
关键词:
摘要: Recent genome-wide association studies identified several novel risk genes for type 2 diabetes. The majority of these diabetes variants confer impaired pancreatic beta cell function. Though the molecular mechanisms by which common genetic variation within loci affects function are not completely understood, may alter glucose-stimulated insulin secretion, proinsulin conversion, and incretin signals. In humans, effect is mediated secretion insulinotropic action two peptide hormones, glucose-dependent polypeptide glucagon-like peptide-1. This review article aims to give an overview that were found associate with or action, paying special attention potential underlying mechanisms.
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