Coronavirus envelope protein: current knowledge

摘要: Coronaviruses (CoVs) primarily cause enzootic infections in birds and mammals but, the last few decades, have shown to be capable of infecting humans as well. The outbreak severe acute respiratory syndrome (SARS) 2003 and, more recently, Middle-East (MERS) has demonstrated lethality CoVs when they cross species barrier infect humans. A renewed interest coronaviral research led discovery several novel human since then much progress been made understanding CoV life cycle. envelope (E) protein is a small, integral membrane involved aspects virus’ cycle, such assembly, budding, formation, pathogenesis. Recent studies expanded on its structural motifs topology, functions an ion-channelling viroporin, interactions with both other proteins host cell proteins. This review aims establish current knowledge E by highlighting recent that comparing it previous knowledge. It also compares viral similar nature speculate relevance these new findings. Good but still remains unknown this identified some gaps suggestions for consideration future research. most SARS-CoV E, specific requirements cycle well mechanisms behind Data shows critical lacking make promising vaccine candidates. high mortality rate certain CoVs, along their ease transmission, underpins need into molecular biology which can aid production effective anti-coronaviral agents CoVs.