Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications

摘要: Molecular imaging is an emerging strategy for in vivo visualization of cancer over time based on biological mechanisms disease activity. Optical methods offer a number advantages real-time detection, particularly the epithelium hollow organs and ducts, by using broad spectral range light that spans from visible to near-infrared. Targeted ligands are being developed improved molecular specificity. These platforms include small molecule, peptide, affibody, activatable probes, lectin, antibody. Fluorescence labeling used provide high image contrast. This methodology clinically useful early detection identifying localizing suspicious lesions may not otherwise be seen serves as guide tissue biopsy surgical resection. Visualizing expression patterns also determine best choice therapy monitor efficacy. A these agents overcoming key challenges clinical translation validated wide human cancers.