The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis
作者： C. Zaragoza , C. Ocampo , M. Saura , M. Leppo , X.-Q. Wei
关键词:
摘要: The host response to Coxsackievirus infection is complex, including T lymphocytes, B natural killer cells, and macrophages. Although induces expression of inducible nitric oxide synthase (NOS2; EC 1.14.13.39) in macrophages, the precise role NOS2 myocarditis has been unclear. We show, by using mice homozygous for a disrupted allele, that replicates higher titers NOS2−/− mice, lacking clears virus more slowly than wild-type host, much severe infected mice. These data show crucial mouse.
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