Carbenoxolone pretreatment and treatment of posttraumatic epilepsy.
作者： Weiguan Chen , Zhiwei Gao , Yaohui Ni , Zhenxiang Dai , None
DOI: 10.3969/J.ISSN.1673-5374.2013.02.010
关键词:
摘要: Gap junction blocking agents can inhibit spontaneous discharge frequency in cells. We established a rat model of posttraumatic epilepsy induced using ferric ions. Rats were intraperitoneally injected with carbenoxolone, 20 mg/kg, prior to and 30 minutes after establishment, once day for 14 consecutive days. Immunohistochemistry showed glial cell proliferation around cortical focus significantly increased connexin expression epilepsy. However, carbenoxolone pretreatment or treatment reduced the cortex, inhibited fibrillary acidic protein ameliorated seizure degree rats. These findings indicate that large amounts abnormal gap generation play role epilepsy, may prevent treat this disease.
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