作者: Doriano Fabbro , Sandra W Cowan-Jacob , Henrik Moebitz
DOI: 10.1111/BPH.13096
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摘要: Many human malignancies are associated with aberrant regulation of protein or lipid kinases due to mutations, chromosomal rearrangements and/or gene amplification. Protein and represent an important target class for treating disorders. This review focus on ‘the 10 things you should know about their inhibitors', including a short introduction the history inhibitors ending perspective kinase drug discovery. Although ‘10 things’ have been, certain extent, chosen arbitrarily, they cover in comprehensive way past present efforts discovery summarize status quo current as well knowledge structure binding modes. Besides describing potentials drugs, this also limitations, particularly how circumvent emerging resistance against oncological indications.