The anxiolytic-like effects of ginsenoside Rg3 on chronic unpredictable stress in rats.
作者： Jia-ning Xu , Li-fang Chen , Jun Su , Zhi-li Liu , Jie Chen
DOI: 10.1038/S41598-018-26146-5
关键词:
摘要: The present study is to evaluate the anxiolytic-like activities underlying ginsenoside Rg3 (GRg3). were induced by GRg3 (20 and 40 mg/kg, i.g), evidenced blocking decreased time entries in open arms elevated plus maze test reversing increased latency feed novelty-suppressed feeding test. In addition, levels on progesterone, allopregnanolone, serotonin (5-HT) prefrontal cortex hippocampus of chronic unpredictable stress (CUS) blocked i.g). Furthermore, corticotropin releasing hormone, corticosterone adrenocorticotropic hormone Collectively, effects produced associated with normalization neurosteroids biosynthesis, serotonergic system as well HPA axis dysfunction.
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