Lymph Nodes Inhibit T-cell Effector Functions Locally by Establishing Acidic Niches

摘要: Abstract Lymph nodes are an essential component of the adaptive immune response where antigen-presenting cells closely housed with their cognate effector cells. Protection lymph node resident from activated in such close quarters would need to be robust and reversible. Effector functions T-cells profoundly reversibly inhibited by acidic microenvironment. The underlying mechanisms this inhibition unknown, but may relate glycolysis, which is obligatory for expression functions. Here, we demonstrate that acidification rapidly potently inhibits monocarboxylate transporter-dependent lactic acid efflux, dually glycolysis end-product accumulation reducing cytoplasmic pH. Based on robustness these responses, propose acid-evoked T-cell physiologically important, a natural site modulation. Using multiple imaging techniques, show paracortical T-zones highly acidic. We further can dendritic at low pH, restored upon increasing Thus, describe novel physiological mechanism whereby kept stasis acidosis whilst nodes.