Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies
作者： Salvador Harguindey , Julian Polo Orozco , Khalid O Alfarouk , Jesús Devesa , None
DOI: 10.3390/IJMS20174278
关键词:
摘要: The treatment of cancer has been slowly but steadily progressing during the last fifty years. Some tumors with a high mortality in past are curable nowadays. However, there is one striking exception: glioblastoma multiforme. No real breakthrough hitherto achieved this tumor ominous prognosis and very short survival. Glioblastomas, being highly glycolytic malignancies strongly pH-dependent driven by sodium hydrogen exchanger 1 (NHE1) other proton (H+) transporters. Therefore, those pathologies where lessons recently learnt from new pH-centered anticancer paradigm may soon bring promising change to treatment. This contribution will discuss how pH-centric molecular, biochemical metabolic perspective introduce some urgently needed integral novel treatments. Such prospective therapeutic approach for malignant brain developed here, either be used alone or combination more standard therapies.
mdpi.com
sci-hub.se 参考文章(185)
W H Moolenaar, Effects of growth factors on intracellular pH regulation. Annual Review of Physiology. ,vol. 48, pp. 363- 376 ,(1986) , 10.1146/ANNUREV.PH.48.030186.002051
Khalid O Alfarouk, Daniel Verduzco, Cyril Rauch, Abdel Khalig Muddathir, HH Bashir Adil, Gamal O Elhassan, Muntaser E Ibrahim, Julian David Polo Orozco, Rosa Angela Cardone, Stephan J Reshkin, Salvador Harguindey, None, Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question Oncoscience. ,vol. 1, pp. 777- 802 ,(2014) , 10.18632/ONCOSCIENCE.109
Tomoda, Rapid decrease of intracellular pH associated with inhibition of Na+/H+ exchanger precedes apoptotic events in the MNK45 and MNK74 gastric cancer cell lines treated with 2-aminophenoxazine-3-one. Oncology Reports. ,vol. 25, pp. 341- 346 ,(2011) , 10.3892/OR.2010.1082
Wilfred Lieberthal, Veronica Triaca, Jason S. Koh, Patrick J. Pagano, Jerrold S. Levine, Role of superoxide in apoptosis induced by growth factor withdrawal American Journal of Physiology-renal Physiology. ,vol. 275, ,(1998) , 10.1152/AJPRENAL.1998.275.5.F691
Emanuela Binello, Isabelle M. Germano, Targeting glioma stem cells: A novel framework for brain tumors Cancer Science. ,vol. 102, pp. 1958- 1966 ,(2011) , 10.1111/J.1349-7006.2011.02064.X
Nevin McVicar, Alex X. Li, Susan O. Meakin, Robert Bartha, Imaging chemical exchange saturation transfer (CEST) effects following tumor‐selective acidification using lonidamine NMR in Biomedicine. ,vol. 28, pp. 566- 575 ,(2015) , 10.1002/NBM.3287
VA Levin, P Giglio, VK Puduvalli, J Jochec, MD Groves, WKA Yung, K Hess, None, Combination chemotherapy with 13-cis-retinoic acid and celecoxib in the treatment of glioblastoma multiforme. Journal of Neuro-oncology. ,vol. 78, pp. 85- 90 ,(2006) , 10.1007/S11060-005-9062-4
Mark L. Hartman, Rong Xu, Brenda J. Crowe, Leslie L. Robison, Eva Marie Erfurth, David L. Kleinberg, Alan G. Zimmermann, Whitney W. Woodmansee, Gordon B. Cutler, John J. Chipman, Shlomo Melmed, , Prospective Safety Surveillance of GH-Deficient Adults: Comparison of GH-Treated vs Untreated Patients The Journal of Clinical Endocrinology and Metabolism. ,vol. 98, pp. 980- 988 ,(2013) , 10.1210/JC.2012-2684
Ksenya Shchors, Aristea Massaras, Douglas Hanahan, Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit Cancer Cell. ,vol. 28, pp. 456- 471 ,(2015) , 10.1016/J.CCELL.2015.08.012
Andressa Bernardi, Maria C. Jacques-Silva, Andrés Delgado-Cañedo, Guido Lenz, Ana M.O. Battastini, Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines European Journal of Pharmacology. ,vol. 532, pp. 214- 222 ,(2006) , 10.1016/J.EJPHAR.2006.01.008