Minimum fungicidal concentrations of amphotericin B for bloodstream Candida species.
作者： Emilia Cantón , Javier Pemán , Angel Viudes , Guillermo Quindós , Miguel Gobernado
DOI: 10.1016/S0732-8893(02)00525-4
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摘要: Abstract Minimum fungicidal concentrations (MFCs) of amphotericin B were obtained for 165 bloodstream isolates (104 Candida parapsilosis, 14 C.glabrata, 13 C.tropicalis, 15 C.krusei, and 19 C.albicans ) 36 C.dubliniensis from oropharyngeal infections. inhibitory (MICs) determined by the M27-A microdilution method. MFCs (≥99.9% killing) following MIC determination (inoculum size, 10 4 CFU/ml) seeding entire volume all clear wells. The best activity was C. albicans, (MFC 90 1 μg/ml) lowest C.parapsilosis, C.tropicalis C.glabrata 16 μg/ml). Although ≥16× some isolates, including glabrata, overall ≥2× MICs. However, major differences between MICs observed C.parapsilosis (3.8% 8.9%, respectively, tolerant: MFC ≥32MIC). glabrata ≥2 μg/ml. By this more stringent method we found substantial those previously reported spp.
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