New silica nanostructure for the improved delivery of topical antibiotics used in the treatment of staphylococcal cutaneous infections.
作者： Alexandru Mihai Grumezescu , Cristina Daniela Ghitulica , Georgeta Voicu , Keng-Shiang Huang , Chih-Hui Yang
DOI: 10.1016/J.IJPHARM.2013.07.016
关键词:
摘要: In this paper, we report the synthesis, characterization (FT-IR, XRD, BET, HR-TEM) and bioevaluation of a novel γ-aminobutiric acid/silica (noted GABA-SiO₂ or γ-SiO₂) hybrid nanostructure, for improved release topical antibiotics, used in treatment Staphylococcus aureus infections. showed IR bands which were assigned to Si-O-Si (stretch mode). The XRD pattern broad peak range 18-30° (2θ), indicating an amorphous structure. Based on BET analysis, estimations about surface area (438.14 m²/g) pore diameters (4.76 nm) done. TEM observation reveals that prepared structure presented homogeneity average size particles not exceeding 10nm. nanostructure has significantly anti-staphylococcal activity bacitracin kanamycin sulfate, as demonstrated by drastic decrease minimal inhibitory concentration respective antibiotics loaded nanostructure. These results, correlated with high biocompatibility porous structure, are highlighting possibility using carrier local delivery antimicrobial substances lower active doses, thus reducing their cytotoxicity side-effects.
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sci-hub.se 参考文章(27)
Li-June Ming, Jon D. Epperson, Metal binding and structure-activity relationship of the metalloantibiotic peptide bacitracin. Journal of Inorganic Biochemistry. ,vol. 91, pp. 46- 58 ,(2002) , 10.1016/S0162-0134(02)00464-6
Margarita D Popova, Ágnes Szegedi, Iliyan N Kolev, Judit Mihály, Borislav S Tzankov, Georgi Tz Momekov, Nikolai G Lambov, Krassimira P Yoncheva, None, Carboxylic modified spherical mesoporous silicas аs drug delivery carriers International Journal of Pharmaceutics. ,vol. 436, pp. 778- 785 ,(2012) , 10.1016/J.IJPHARM.2012.07.061
Chia-Hui Lin, Shih-Hsun Cheng, Wei-Neng Liao, Pei-Ru Wei, Ping-Jyun Sung, Ching-Feng Weng, Chia-Hung Lee, Mesoporous silica nanoparticles for the improved anticancer efficacy of cis-platin. International Journal of Pharmaceutics. ,vol. 429, pp. 138- 147 ,(2012) , 10.1016/J.IJPHARM.2012.03.026
Swapan K. Das, Manas K. Bhunia, Debrup Chakraborty, Anisur Rahman Khuda-Bukhsh, Asim Bhaumik, Hollow spherical mesoporous phosphosilicate nanoparticles as a delivery vehicle for an antibiotic drug Chemical Communications. ,vol. 48, pp. 2891- 2893 ,(2012) , 10.1039/C2CC17181C
M. Carmen Chifiriuc, E. Ilinca, A. Mihai Grumezescu, D. Mihaiescu, G. Mihaescu, L. Marutescu, Influence of hybrid inorganic/organic mesoporous and nanostructured materials on the cephalosporins' efficacy on different bacterial strains Iet Nanobiotechnology. ,vol. 6, pp. 156- 161 ,(2012) , 10.1049/IET-NBT.2011.0066
P. Frutos, E. Diez-Peña, G. Frutos, J.M. Barrales-Rienda, Release of gentamicin sulphate from a modified commercial bone cement. Effect of (2-hydroxyethyl methacrylate) comonomer and poly(N-vinyl-2-pyrrolidone) additive on release mechanism and kinetics. Biomaterials. ,vol. 23, pp. 3787- 3797 ,(2002) , 10.1016/S0142-9612(02)00028-5
Alan R. Potts, Tatiana Psurek, Cassandra Jones, Luba Parris, Ahalya Wise, Validation of a quantitative HPLC method for bacitracin and bacitracin zinc using EDTA as a mobile-phase modifier. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 70, pp. 619- 623 ,(2012) , 10.1016/J.JPBA.2012.06.016
Dirk Konz, Andrea Klens, Kurt Schörgendorfer, Mohamed A. Marahiel, The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases Chemistry & Biology. ,vol. 4, pp. 927- 937 ,(1997) , 10.1016/S1074-5521(97)90301-X
Magali Gary-Bobo, Youssef Mir, Cédric Rouxel, David Brevet, Ouahiba Hocine, Marie Maynadier, Audrey Gallud, Afitz Da Silva, Olivier Mongin, Mireille Blanchard-Desce, Sébastien Richeter, Bernard Loock, Philippe Maillard, Alain Morère, Marcel Garcia, Laurence Raehm, Jean-Olivier Durand, Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: Drug delivery, one and two-photon photodynamic therapy International Journal of Pharmaceutics. ,vol. 432, pp. 99- 104 ,(2012) , 10.1016/J.IJPHARM.2012.04.056
V. Jokanović, B. Čolović, M. Dutour Sikirić, V. Trajković, A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying. Ultrasonics Sonochemistry. ,vol. 20, pp. 535- 545 ,(2013) , 10.1016/J.ULTSONCH.2012.08.015