Role of free fatty acids on cardiac autonomic nervous system in noninsulin-dependent diabetic patients: effects of metabolic control.
作者： Daniela Manzella , Michelangela Barbieri , Maria Rosaria Rizzo , Emilia Ragno , Nicola Passariello
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摘要: Decreased heart rate variability (HRV) is a risk factor for cardiovascular mortality. Elevated plasma free fatty acid (FFA) levels decrease HRV in healthy subjects. Thus, we investigated the effect of changes FFA on HRV, non–insulin-dependent diabetes (NIDDM) patients. Thirty NIDDM patients from diabetic neuropathy volunteered study made by two phases. In A, along 10% lipid emulsion infusion + heparin (n = 15) or saline (control study; n were investigated. B, all 30) underwent further determination after 3 months improved metabolic control achieved intensified insulin treatment. increased (P < 0.001) and catecholamine concentrations 0.005), mean arterial blood pressure low frequency/high frequency (LF/HF) ratio 0.001). Delta correlated with delta LF/HF (r 0.57; P< 0.02). Along infusion, metabolic...
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