Association between urinary metabolic profile and the intestinal effects of cocoa in rats.
作者： Malen Massot-Cladera , Jordi Mayneris-Perxachs , Adele Costabile , Jonathan R. Swann , Àngels Franch
DOI: 10.1017/S0007114517000496
关键词:
摘要: The aim of this study was to elucidate the relationship between urinary metabolic fingerprint and effects cocoa fibre on body weight, hormone metabolism, intestinal immunity microbiota composition. To effect, Wistar rats were fed, for 3 weeks, a diet containing 10 % (C10) or two other diets with same proportion fibres: one based (CF) another inulin as reference (REF) diet. rats' 24 h urine samples analysed by an untargeted 1H NMR spectroscopy-based metabonomic approach. Concentrations faecal IgA plasma hormones also quantified. C10 decreased IgA, glucagon-like peptide-1 glucagon concentrations increased ghrelin levels compared those in REF group. Clear differences observed profiles from group CF Urine metabolites derived correlated gut microbiota. Overall, intake alters host bacterial metabolism concerning energy amino acid pathways, leading signature that can be used marker consumption. This profile correlates hormones,
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