Drug release from α, β-poly(N-2-hydroxyethyl)-DL-aspartamide-based microparticles
作者： G. Pitarresi , P. Pierro , G. Giammona , F. Iemma , R. Muzzalupo
DOI: 10.1016/J.BIOMATERIALS.2003.11.015
关键词:
摘要: Abstract Spherical pH-sensitive microparticles have been prepared by reverse phase suspension polymerization technique. Starting polymer has α , β -poly( N -2-hydroxyethyl)- dl -aspartamide (PHEA) partially derivatized with glycidylmethacrylate (GMA). PHEA-GMA copolymer (PHG) crosslinked in the presence of acrylic acid (AA) or methacrylic (MA) at various concentration. The obtained characterized FT-IR spectrophotometry, particle size distribution analysis and scanning electron microscopy. In order to information about water affinity samples, swelling measurements carried out aqueous media which simulate some biological fluids. possibility employ samples as investigated performing vitro release studies. Experimental data showed that rate from these depends on environmental pH chemical structure drug.
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