(E)-Selective Friedel–Crafts acylation of alkynes to β-chlorovinyl ketones: defying isomerizations in batch reactions by flow chemistry approaches
作者： Hyungmo Koo , Hun Young Kim , Kyungsoo Oh
DOI: 10.1039/C9QO00217K
关键词:
摘要: The Friedel–Crafts acylation of alkynes stereoselectively provides (Z)-β-chlorovinyl ketones, whereas the AlCl3-promoted reaction yields a mixture stereoisomeric β-chlorovinyl ketones. To develop (E)-selective synthesis flow chemistry approach was devised for that defies facile (E) → (Z) isomerization under conditions. Compared to batch reactions, fast, clean, high yielding, and stereoselective synthetic route (E)-β-chlorovinyl
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sci-hub.se 参考文章(33)
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