Roles of competing endogenous RNAs in gastric cancer
作者： Ye Hu , Haiying Tian , Jie Xu , Jing-Yuan Fang
DOI: 10.1093/BFGP/ELV036
关键词:
摘要: Long noncoding RNA (lncRNA) is >200 nucleotides long and lacks coding ability. LncRNA was regarded as transcript noise, until emerging results showed its roles in development, homeostasis carcinogenesis. LncRNAs containing microRNA (miRNA) response elements could compete with the miRNA target gene regulate expression through decreasing free functional miRNA. Such lncRNA called competing endogenous (ceRNA), 'lncRNA-miRNA' interaction appreciably enriches world of RNA-RNA regulation. Gastric cancer involves dysregulation both protein-coding genes genes, ceRNA regulatory mechanism may participate this pathogenic process. In review, we discuss recent findings on ceRNAs gastric
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