Identifying survival-associated ceRNA clusters in cholangiocarcinoma.
作者： Ming Wan , Fu-Min Zhang , Zheng-Long Li , Peng-Cheng Kang , Ping-Ming Jiang
DOI: 10.3892/OR.2016.4934
关键词:
摘要: Abstract Competing endogenous RNAs (ceRNAs) represent a novel layer regulations of long non-coding (lncRNAs) and genes that play important roles in cancer pathogenesis by binding microRNAs (miRNAs). However, the competition mechanism ceRNAs cholangiocarcinoma (CHOL) is not fully understood. In this study, we constructed dysregulated ceRNA competitive network (CCEN) to globally characterize competing difference between CHOL normal tissues. Then, integrated affinity propagation Kaplan‑Meier (K-M) methods identify functional clusters associated with survival. A total 7 key were identified. Further annotation analyses found Cluster23 Cluster32 involved cell based functions, loss relations may contribute CHOL, disturbing biological processes, such as 'Pathway cancer', MAPK Neurotrophin signaling pathway. This study provides further insights into understanding CHOL.
sci-hub.se 参考文章(61)
C. WANG, G. YAN, Y. ZHANG, X. JIA, P. BU, Long non-coding RNA MEG3 suppresses migration and invasion of thyroid carcinoma by targeting of Rac1. Neoplasma. ,vol. 62, pp. 541- 549 ,(2015) , 10.4149/NEO_2015_065
Tianjing Zheng, Jinjiang Chou, Feng Zhang, Yu Liu, Haiwei Ni, Xiaoman Li, Lufeng Zheng, Tingting Tang, Liang Jin, Tao Xi, CXCR4 3'UTR functions as a ceRNA in promoting metastasis, proliferation and survival of MCF-7 cells by regulating miR-146a activity. European Journal of Cell Biology. ,vol. 94, pp. 458- 469 ,(2015) , 10.1016/J.EJCB.2015.05.010
Jianguo Wang, Haiyang Xie, Qi Ling, Di Lu, Zhen Lv, Runzhou Zhuang, Zhikun Liu, Xuyong Wei, Lin Zhou, Xiao Xu, Shusen Zheng, Coding-noncoding gene expression in intrahepatic cholangiocarcinoma Translational Research. ,vol. 168, pp. 107- 121 ,(2016) , 10.1016/J.TRSL.2015.07.007
Ting-Xun Lu, Ken H. Young, Wei Xu, Jian-Yong Li, TP53 dysfunction in diffuse large B-cell lymphoma. Critical Reviews in Oncology Hematology. ,vol. 97, pp. 47- 55 ,(2016) , 10.1016/J.CRITREVONC.2015.08.006
Subbiah Pugazhenthi, Albina Nesterova, Purevsuren Jambal, Gerald Audesirk, Marcey Kern, Leigh Cabell, Eva Eves, Marsha R. Rosner, Linda M. Boxer, Jane E.-B. Reusch, Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons. Journal of Neurochemistry. ,vol. 84, pp. 982- 996 ,(2003) , 10.1046/J.1471-4159.2003.01606.X
Pattaya Seeree, Phorutai Pearngam, Supeecha Kumkate, Tavan Janvilisri, An Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of Cholangiocarcinoma. Comparative and Functional Genomics. ,vol. 2015, pp. 179528- 179528 ,(2015) , 10.1155/2015/179528
Tanmoy Mondal, Santhilal Subhash, Roshan Vaid, Stefan Enroth, Sireesha Uday, Björn Reinius, Sanhita Mitra, Arif Mohammed, Alva Rani James, Emily Hoberg, Aristidis Moustakas, Ulf Gyllensten, Steven J.M. Jones, Claes M Gustafsson, Andrew H Sims, Fredrik Westerlund, Eduardo Gorab, Chandrasekhar Kanduri, MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures Nature Communications. ,vol. 6, pp. 7743- 7743 ,(2015) , 10.1038/NCOMMS8743
DEBO KONG, FENG CHEN, NI SIMA, Inhibition of focal adhesion kinase induces apoptosis in bladder cancer cells via Src and the phosphatidylinositol 3-kinase/Akt pathway Experimental and Therapeutic Medicine. ,vol. 10, pp. 1725- 1731 ,(2015) , 10.3892/ETM.2015.2745
Xinling Zhang, Leina Ma, Jieqiong Qi, Hui Shan, Wengong Yu, Yuchao Gu, MAPK/ERK signaling pathway-induced hyper-O-GlcNAcylation enhances cancer malignancy. Molecular and Cellular Biochemistry. ,vol. 410, pp. 101- 110 ,(2015) , 10.1007/S11010-015-2542-8
Yvonne Tay, Florian A Karreth, Pier Paolo Pandolfi, Aberrant ceRNA activity drives lung cancer Cell Research. ,vol. 24, pp. 259- 260 ,(2014) , 10.1038/CR.2014.21