p53 codon 72 polymorphism is associated with susceptibility to hepatocellular carcinoma in the Turkish population: a case–control study

作者: Ahmet Taner Sümbül , Hikmet Akkız , Süleyman Bayram , Aynur Bekar , Ersin Akgöllü

DOI: 10.1007/S11033-011-0903-2

关键词:

摘要: The tumor suppressor p53 gene plays a crucial role in preventing carcinogenesis through its ability to induce cell cycle arrest and apoptosis following DNA damage oncogene activation. A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 exon 4 determines arginine (Arg) proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain protein. Arg72 Pro72 allele are different from biochemical biological point view many reports suggest that they can modulate individual cancer susceptibility. To determine association Arg72Pro with risk hepatocellular carcinoma (HCC) development Turkish population, hospital-based case–control study was designed consisting 119 subjects HCC cancer-free control matched for age, gender, smoking alcohol status. genotype frequency determined by using polymerase chain reaction-restriction fragment length (PCR-RFLP) assay. Our data shows Pro/Pro is associated increased this population (OR = 3.20, 95% CI: 1.24–8.22, P 0.02). Furthermore, according stratified analysis, significant observed between homozygote subgroups male gender 3.01, 1.14–7.97, 0.03) patients hepatitis B virus (HBV)-related 4.04, 1.46–11.15, 0.007). Because our results first time may be genetic susceptibility factor (especially HBV-infected patients) further independent studies required validate findings larger series, as well ethnic origins.

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