Immunohistochemical expression of heparan sulfate correlates with stromal cell proliferation in breast phyllodes tumors

摘要: Phyllodes tumors are fibroepithelial neoplasms typified by stromal proliferation. We have previously shown the role of pathologic parameters and prognostic significance p53 CD117 protein expression in these tumors. In this study, we evaluated heparan sulfate, which has been implicated many biological processes such as cell adhesion, embryogenesis, tumorigenesis (including malignant transformation mammary cells) 232 breast phyllodes used a monoclonal antibody, 10E4, to examine localization sulfate immunohistochemistry. The immunoreactivity both epithelial components was examined analyzed with pathological other immunohistochemical markers, including p53, MIB1, bcl2, CD117. Stromal 10E4 significantly associated tumor grade, MIB1 proliferating cells, suggesting that may participate growth.