Persistent dysfunctional frontal lobe activation in former smokers

摘要: Chronic smoking and nicotine exposure are accompanied by impaired cognitive task performance, modulated cerebral activity in brain imaging studies, neuritic damage experimental animals. The profile of the described dysfunctions matches frontal lobe circuits which also play a role reward processing reinforcement behavior. However, it is largely unknown if reversible or persist during long term abstinence. Cortical activation auditory target (oddball task, P300 component) was recorded with 32-channel EEG 247 healthy subjects consisting 84 smokers, 53 former smokers (mean time abstinence 11.9 years), 110 never smokers. Both current exhibited significantly diminished amplitudes (Cz, Pz) relative to Neuroelectric source analysis (low resolution electromagnetic tomography) revealed hypoactivation anterior cingulate, orbitofrontal, prefrontal cortex compared A similar observed For first time, evidence provided that dysfunctional networks present abstainers.