Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer.
作者： C. R. Graveel , J. D. DeGroot , Y. Su , J. Koeman , K. Dykema
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摘要: Understanding the signaling pathways that drive aggressive breast cancers is critical to development of effective therapeutics. The oncogene MET associated with decreased survival in cancer, yet role plays various cancer subtypes unclear. We describe a knockin mouse mutationally activated Met (Metmut) develops high incidence diverse mammary tumors basal characteristics, including metaplasia, absence progesterone receptor and ERBB2 expression, expression cytokeratin 5. With gene tissue microarray analysis, we show human significantly correlated estrogen negative/ERBB2 negative cancers. Few treatment options exist for or trastuzumab-resistant subtypes. conclude from these studies may play most be rational therapeutic target.
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