Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in Cosmc

摘要: Neoplastic lesions typically express specific carbohydrate antigens on glycolipids, mucins, and other glycoproteins. Such are often under epigenetic control subject to reversion loss upon therapeutic selective pressure. We report here that two of the most common tumor-associated antigens, Tn sialyl (STn), result from somatic mutations in gene Cosmc encodes a molecular chaperone required for formation active T-synthase. Diverse neoplastic lesions, including colon cancer melanoma-derived cells lines, expressed both STn antigen due loss-of-function Cosmc. In addition, human cervical specimens showed expression Tn/STn were also found have heterozygosity cross-linked locus. This is first example multiple types cancers cause global alterations cell surface expression.