Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer
作者： Heikki J. Järvinen , Markku Aarnio , Harri Mustonen , Katja Aktan–Collan , Lauri A. Aaltonen
DOI: 10.1016/S0016-5085(00)70168-5
关键词:
摘要: Abstract Background & Aims: Identification of the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome enables prevention (CRC) by means colonoscopy and polypectomies. We evaluated efficacy screening in a controlled trial over 15 years. Methods: Incidence CRC survival were compared 2 cohorts at-risk members 22 families with HNPCC. Colonic at 3-year intervals was arranged for 133 subjects; 119 control subjects had no screening. Genetic testing offered to whose causative mutation known. Results: developed 8 screened (6%) 19 (16 %; P = 0.014). The rate reduced 62%. In mutation-positive alone, rates 18% 41% controls ( 0.02). decrease resulted from removal adenomas 13 individuals (30%) 6 unknown status (40%). All CRCs study group local, causing deaths, 9 deaths caused controls. overall death 10 vs. 26 groups 0.003), 4 12 0.05). Conclusions: Colonoscopic more than halves risk CRC, prevents decreases mortality about 65% HNPCC families. GASTROENTEROLOGY 2000;118:829-834
gastrojournal.org
elsevier.com
sci-hub.se 参考文章(22)
M. S. Rhyu, Molecular Mechanisms Underlying Hereditary Nonpolyposis Colorectal Carcinoma Journal of the National Cancer Institute. ,vol. 88, pp. 240- 251 ,(1996) , 10.1093/JNCI/88.5.240
Alan G. Thorson, Joseph A. Knezetic, Henry T. Lynch, A century of progress in hereditary nonpolyposis colorectal cancer (lynch syndrome) Diseases of the Colon & Rectum. ,vol. 42, pp. 1- 9 ,(1999) , 10.1007/BF02235175
J.R. Jass, S.M. Stewart, J. Stewart, M.R. Lane, Hereditary non-polyposis colorectal cancer — morphologies, genes and mutations Mutation Research. ,vol. 310, pp. 125- 133 ,(1994) , 10.1016/0027-5107(94)90016-7
Neville C. Davis, Elizabeth B. Evans, Jon R. Cohen, David E. Theile, Staging of colorectal cancer. The Australian clinico-pathological staging (ACPS) system compared with Dukes' system. Diseases of The Colon & Rectum. ,vol. 27, pp. 707- 713 ,(1984) , 10.1007/BF02554593
David A. Ahlquist, Aggressive polyps in hereditary nonpolyposis colorectal cancer: Targets for screening Gastroenterology. ,vol. 108, pp. 1590- 1592 ,(1995) , 10.1016/0016-5085(95)90711-4
H.F.A. Vasen, F.M. Nagengast, P. Meera Khan, Interval cancers in hereditary non-polyposis colorectal cancer (Lynch syndrome) The Lancet. ,vol. 345, pp. 1183- 1184 ,(1995) , 10.1016/S0140-6736(95)91016-6
Minna Nyström-Lahti, Paula Kristo, Nicholas C. Nicolaides, Sheng-Yung Chang, Lauri A. Aaltonen, Anu-Liisa Moisio, Heikki J. Järvinen, Jukka-Pekka Mecklin, Kenneth W. Kinzler, Bert Vogelstein, Albert De La Chapelle, Päivi Peltomäki, Founding mutations and Alu-mediated recombination in hereditary colon cancer. Nature Medicine. ,vol. 1, pp. 1203- 1206 ,(1995) , 10.1038/NM1195-1203
Michiko Miyaki, Motoko Konishi, Kiyoko Tanaka, Rei Kikuchi-Yanoshita, Masatoshi Muraoka, Masamichi Yasuno, Tohru Igari, Morio Koike, Mitsuro Chiba, Takeo Mori, Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. Nature Genetics. ,vol. 17, pp. 271- 272 ,(1997) , 10.1038/NG1197-271
H.F.A Vasen, B.G Taal, F.M Nagengast, G Griffioen, F.H Menko, J.H Kleibeuker, G.J.A Offerhaus, P.Meera Khan, Hereditary nonpolyposis colorectal cancer: results of long-term surveillance in 50 families European Journal of Cancer. ,vol. 31, pp. 1145- 1148 ,(1995) , 10.1016/0959-8049(95)00249-I
Hans F. A. Vasen, Marjolein van Ballegooijen, Eric Buskens, Jan K. Kleibeuker, Babs G. Taal, Gerrit Griffioen, Fokko M. Nagengast, Fred H. Menko, P. Meera Khan, A cost-effectiveness analysis of colorectal screening for hereditary nonpolyposis colorectal carcinoma gene carriers†‡ Cancer. ,vol. 82, pp. 1632- 1637 ,(1998) , 10.1002/(SICI)1097-0142(19980501)82:9<1632::AID-CNCR6>3.0.CO;2-C