Hereditary nonpolyposis colorectal cancer: results of long-term surveillance in 50 families

摘要: Abstract A surveillance programme comprising either colonoscopy or sigmoidoscopy plus barium enema every 2–3 years was instituted in 50 hereditary nonpolyposis colorectal cancer (HNPCC) families. The families included 238 patients with (CRC) (mean age at diagnosis: 43.7 years; range: 16–86 years). These had 597 first-degree relatives of whom 493 could be traced and 388 (79%) accepted the invitation for screening. control group were (index patients) symptomatic CRC. average follow-up duration 5 (1–20 Screening led to detection adenomas 33 CRC 11 patients. Pathological examination revealed 1 Dukes' A, 7 B 3 C cancers. In contrast, among 47% advanced (Dukes' distant metastases). 5-year survival screen-detected cases 87% versus 63% group. Of screening group, 4 detected within 1–4 after a negative colonic examination. large proportion polyps found groups showed villous growth pattern and/or high degree dysplasia. We conclude that periodic HNPCC allows an earlier stage than not under surveillance. Because possibly more aggressive nature associated HNPCC, we recommend interval 1–2 years.