A new approach to conformationally restricted peptide analogs: Rigid β-bends. 1. Enkephalin as an example
作者： John L. Krstenansky , Robert L. Baranowski , Bruce L. Currie
DOI: 10.1016/0006-291X(82)91928-3
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摘要: Abstract A means of producing a peptide analogue that is permanently fixed in β-bend conformation has been devised. These analogues are based on appropriately substituted derivatives the ring system, 5H-6-oxo-2,3,4,4a,7,7a-hexahydropyrano [2,3,-b]pyrrole. The substituents chosen to represent relevant side chains amino acids. first this type enkephalin synthesized and was found have same order magnitude activity guinea pig ileum assay as morphine.
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