Sterically stabilized polymeric nanoparticles with a combinatorial approach for multi drug resistant cancer: in vitro and in vivo investigations.
作者： Sobiya Zafar , Lalit Mohan Negi , Anita Kamra Verma , Vijay Kumar , Aakriti Tyagi
DOI: 10.1016/J.IJPHARM.2014.10.061
关键词:
摘要: The present work describes the preparation of sterically stabilize polymeric nanoparticles mitoxantrone dihydrochloride (MTO) along with an efflux transporter (Pgp/BCRP) inhibitor that enhance circulation time and simultaneously surmount problem multidrug resistance (MDR). Mitoxantrone being hydrophilic in nature had very low entrapment efficiency (%E.E.), thus order to further lipophilicity %E.E., it was complexed sodium deoxycholate (SDC) this MTO-SDC-complex used formulate with/without Pgp/BCRP by nanoprecipitation technique characterized for various vitro vivo attributes. In cell line studies were conducted on MCF7, A2780(p) A2780(adr) cells. Furthermore, targeting potential hyaluronic acid (HA) coated CD44 receptors investigated using MCF7 line. A reduction IC50 value observed loaded different lines indicated BCRP/Pgp inhibiting ability formulated nanoparticles. reduced macrophage uptake increased residence blood demonstrated long circulating behaviour enhanced cellular HA cells revealed their potential. exhibits a great targeted chemotherapy overexpressing MDR breast cancer.
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