Association between HLA-DQB1*03:01 and Bullous pemphigoid in Iranian patients.
作者： Ali Akbar Amirzargar , Zeinab Aryanian , Maede Rayati Damavandi , Nafiseh Esmaili , Hossein Mortazavi
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摘要: Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies other ethnic groups showed HLA alleles as genetic predisposing factors for BP. Objective: To investigate the association of and haplotypes BP Iranian population. Methods: Fifty patients 180 geographically matched, healthy individuals control group enrolled into this study. typing (DR DQ alleles) was carried out using polymerase chain reaction based on sequence-specific primers method. Results: Class DQA1 DQB1 a significantly higher frequency HLA-DQA1*05:01 (45% vs. 33%, p=0.03), HLA-DQB1*03:01 (36% 23.6%, p=0.02) HLA-DQB1*04:01 (4% 1.6%, p=0.04) compared controls. For DRB1 allele frequencies, there were no significant disease associations. The DRB1*08:01/DQA1*05:01/DQB1*03:01 (3% 0%, haplotype an increase among Conclusion: Our data suggest that present same predisposition linked previously reported Caucasians.
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