Low plasma levels of cholecalciferol and 13-cis-retinoic acid in tuberculosis: implications in host-based chemotherapy.

摘要: Abstract Objective The aim of this study was to estimate the concentration cholecalciferol and 13- cis -retinoic acid (RA) in plasma pleural fluid patients with tuberculosis (TB) against controls. Methods Plasma levels -RA were measured 22 TB healthy controls their fluids 6 diseased by established high-performance liquid chromatography–based procedure. Results Cholecalciferol 67.45 (10.71) nmol/L 21.40 (8.58) compared 117.43 (18.40) ( P = 0.0049), respectively. level 1.51 (0.72) 6.67 (0.81) not detectable fluid. both agents lower than Conclusion It observed that there is a combined deficiency volunteers. Because are equilibrium active ingredients vitamins A D, we feel these TB. There an evidence concomitant vitamin D supplementation can kill intracellular Mycobacterium in vitro. Therefore, observations made pave path for trial available formulations (cholecalciferol -RA) novel anti-tubercular drug therapy. such approach host-based it has potential treat even multidrug-resistant extensively drug-resistant forms