Comparison of Molecular Changes in Lung Cancers in HIV-Positive and HIV-Indeterminate Subjects
作者： Ignacio I Wistuba , Carmen Behrens , Sara Milchgrub , Arvind K Virmani , Jaishree Jagirdar
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摘要: Context.— Human immunodeficiency virus (HIV) infection has been associated with an increasing incidence of malignancy, and HIV-infected persons have an increased incidence primary lung carcinoma compared with the general population. Objective.— To investigate molecular changes present in HIV-associated lung tumors compare them those carcinomas arising HIV-indeterminate subjects ("sporadic tumors"). Design.—Convenience sample.Subjects.— Archival tissues from 11 HIV-positive 35 of indeterminate HIV status. Setting.—University-based medical centers affiliated hospitals.Main Outcome Measures.— Analysis frequency loss heterozygosity (LOH) microsatellite alteration (MA) using polymerase chain reaction 16 polymorphic microsatellite markers at 8 chromosomal regions frequently deleted cancer. Presence of human papillomavirus (HPV) sequences. Results.— The overall LOH all tested the frequencies most individual were similar 2 groups. Frequency MA tumors (0.18) was 6-fold higher than sporadic (0.03) (P<.001). At least 1 10 (91%) vs 17 (48%) 35 sporadic (P=.02). Molecular independent of tumor stage gender. HPV sequences not detected the HIV-associated carcinomas. Conclusions.— Microsatellite alterations, which reflect widespread genomic instability, occur greatly increased carcinomas. Although the mechanism underlying development MAs is unknown, it may play a crucial role many tumors.
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