Ubiquitous somatic alterations at microsatellite alleles occur infrequently in Barrett's-associated esophageal adenocarcinoma.

摘要: Microsatellite alterations have been documented in a subset of sporadic tumors, including those the colon, lung, bladder, stomach, and esophagus. This study frequency microsatellite at 139 loci, comprising predominantly dinucleotide tetranucleotide repeat units, 17 cases primary esophageal adenocarcinoma arising against background Barrett's metaplasia. Each tumor demonstrated least one locus studied. Widespread alterations, occurring 45.3% (58 128) loci tested, were detected single case. The remaining 16 tumors exhibited low levels instability, ranging from 0.8% (1 to 8.1% (10 123) tested. case with ubiquitous somatic showed no significant difference incidence novel alleles di- loci. showing level 3.3-fold higher compared These data suggest that considered phenotypic expression defective mismatch repair, occur infrequently Barrett's-associated adenocarcinoma. However, majority these demonstrate perhaps reflecting inherent instability markers.