A simple Tracerlab module modification for automated on-column [11C]methylation and [11C]carboxylation
作者： Filippo Lodi , Silvia Trespidi , Donato Di Pierro , Mario Marengo , Mohsen Farsad
DOI: 10.1016/J.APRADISO.2006.10.011
关键词:
摘要: A modification of commercial [11C]methylation module which can be implemented for both on-column and [11C]carboxylation in the same automated system is described. This configuration was applied to solid-phase synthesis N-[11C]methyl-choline ([11C]choline) L-(S-methyl-[11C])methionine ([11C]methionine), using [11C]CH(3)I as methylating agent, well [11C]acetate by with [11C]CO2 methylmagnesium chloride high reproducible radiochemical yields short reaction time, demonstrating a fast reliable tool production these [11C]radiopharmaceuticals clinical use.
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