The translocator protein ligand [18F]DPA-714 images glioma and activated microglia in vivo
作者： Alexandra Winkeler , Raphael Boisgard , Ali R. Awde , Albertine Dubois , Benoit Thézé
DOI: 10.1007/S00259-011-2041-4
关键词: In vivo 、 DPA-714 、 Chemistry 、 Glioma 、 Radioligand 、 Neuroinflammation 、 Cancer research 、 Pathology 、 Microglia 、 Receptor 、 Translocator protein
摘要: Purpose In recent years there has been an increase in the development of radioligands targeting 18-kDa translocator protein (TSPO). TSPO expression is well documented activated microglia and serves as a biomarker for imaging neuroinflammation. In addition, also reported to be overexpressed number cancer cell lines human tumours including glioma. Here we investigated use [18F]DPA-714, new positron emission tomography (PET) radioligand image glioma vivo.
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