Dietary risk factors for colon and rectal cancers: a comparative case-control study.

摘要: BACKGROUND: In Japan, the incidence rate of colon cancer has more rapidly increased than that rectal cancer. The differential secular trends may be due to different dietary factors in development and cancers. METHODS: To compare risk between cancers, we undertook a case-control study at Aichi Cancer Center Hospital, Japan. Subjects were 507 patients with newly diagnosed (n = 265) 242) 2,535 cancer-free outpatients (controls). Intakes nutrients food groups assessed frequency questionnaire, multivariate-adjust-ed odds ratios (ORs) estimated using unconditional logistic models. RESULTS: We found decreasing increasing intakes calcium insoluble fiber; multivariate ORs across quartiles intake 1.00, 0.90, 0.80, 0.67 (trend p 0.040), 0.69, 0.64, 0.65 0.027), respectively. For cancer, higher consumption carotene meat was associated reduced risk; corresponding 1.10, 0.71, 0.70 for 0.028), 0.99, 0.68, 0.72 0.036). Carbohydrate positively correlated (ORs over quartiles: 1.14, 1.42, 1.54; trend 0.048). This association stronger women, while fat inversely female CONCLUSIONS: Dietary appear considerably differ