Mutational analysis of the tyrosine kinome in colorectal cancers
作者： Alberto Bardelli , D Williams Parsons , Natalie Silliman , Janine Ptak , Steve Szabo
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摘要: Tyrosine kinases (TKs) are central regulators of signaling pathways that control differentiation, transcription, cell cycle progression, apoptosis, motility, and invasion ( [1][1] ). Although a few TK genes have been shown to be mutationally altered in specific human cancers ), it is not
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