Liberal Versus Restrictive Fluid Administration to Improve Recovery After Laparoscopic Cholecystectomy: A Randomized, Double-Blind Study

摘要: Limited scientific evidence on optimal intraoperative fluid management has resulted in large variations of administered regimens daily practice. Currently, there is a tendency toward liberal perioperative administration,1 and laparoscopic cholecystectomy, administration 1 to 4 L crystalloid been reported.1 The stress response surgery profoundly alters homeostasis leading conservation. Primary mediators are aldosterone, antidiuretic hormone, the renin–angiotensin system. However, effect different these hormonal responses largely unknown.1 Although high volumes may be deleterious connection with major surgical procedures,1,2 studies minor (ambulatory) suggest that substitution aiming correct preoperative dehydration improve some parameters recovery (drowsiness dizziness).3 We therefore investigated effects 2 Ringer’s lactate (LR) (40 mL/kg 15 mL/kg) for cholecystectomy pulmonary function, exercise capacity, (aldosterone, hormone [ADH], angiotensin II, atrial natriuretic peptide [ANP], renin), balance function as primary outcome assessments. Furthermore, pain, nausea, vomiting, hospital stay, were assessed.