Approach to Adolescent Polycystic Ovary Syndrome (PCOS) in the Pediatric Endocrine Community in the USA

摘要: Objective Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy in adult women, and emerging as a cause of menstrual disturbances adolescent population. Insulin resistance, which considered one its underlying causes, has increased substantially past decade, putting more girls at risk for PCOS complications. Our objective was to survey pediatric endocrinologists' approach diagnosis treatment population, there presently no structured recommended this problem. Design/methods A questionnaire sent 839 members Lawson Wilkins Pediatric Endocrine Society (LWPES). total 176 (21%) responses received analyzed. REDULTS: The majority participants would consider initiating work-up an with oligomenorrhea or secondary amenorrhea 12-24 months after menarche. following selected baseline teenager by than 50% participants: LH FSH, free testosterone, prolactin, 17-OH-progesterone, DHEAS glucose/insulin measurements. For PCOS, surveyed endocrinologists suggested estrogen/progesterone combination. Metformin appropriate general population 30% obese teenagers 68% endocrinologists. Conclusions findings indicate trend among towards earlier irregularities adolescents--unlike traditional practice waiting 2 years Most evaluation insulin resistance using measurement, but only small percentage considers performing OGTT these patients. Even though combination preferred therapeutic approach, metformin therapy it adolescents PCOS.