gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini.
作者： W D Henner , L O Rodriguez , S M Hecht , W A Haseltine
DOI: 10.1016/S0021-9258(18)33104-1
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摘要: Gamma irradiation of DNA in aqueous solution produces single strand breaks with two types of 3'-termini. These termini have been identified as a simple phosphoryl group and a glycolate moiety attached to the 3'-phosphoryl group via the 2"-OH of glycolic acid. Irradiation of 5'-end labeled poly (dG) produces compounds that comigrate with authentic 3', 5'-dGDP and 2'-deoxyguanosine-3'-(phospho-2"-O-glycolic acid-5'-monophosphate by thin layer chromatography and polyacrylamide gel electrophoresis. Irradiation of poly (dGdC) …
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