Comparison of chromosomal aberrations in primary colorectal carcinomas to their pulmonary metastases

摘要: Pulmonary metastases (PM) are frequent in colorectal carcinoma (CRC). However, little is known about the chromosomal imbalances CRC that accompany metastatic pulmonary disease. We investigated tumor specimens of (n=30) and their corresponding PM by comparative genomic hybridization (CGH). There were no substantial differences degree instability between PM, neither average number copy alterations (ANCA; 6.6 ± 0.8 7.7 0.9) nor gains (2.6 0.5 2.6 0.4), losses (3.6 4.8 0.6), or amplifications (0.4 0.1 0.3 0.1). Basically, similar patterns could be identified both most frequently including at 7, 8q, 13q, 20q, as well 4, 8p, 18q, 20p. differed frequencies for chromosome arm 5q (3 vs. 26%; P=0.012). Losses 4q 11q significantly associated with lower 5-year survival rates (80 24%, P=0.026 74 17%, P=0.007, respectively), they may represent candidates adverse prognostic markers primary CRC.