Sarcomatoid Carcinoma in the Head and Neck: A Population-Based Analysis of Outcome and Survival.

摘要: Objectives To characterize sarcomatoid cell carcinoma (SaC) in head and neck, explore the value of radiotherapy (RT) chemotherapy, build a nomogram to predict prognosis. Study design Retrospective cohort study. Methods In total, 559 patients diagnosed with neck SaC from 2004 2015 were included Surveillance, Epidemiology, End Results program. All cases divided into training (N = 313) validation 246) cohorts according year diagnosis. The analyzed on age, site, sex, race, T stage, N M surgery, RT, chemotherapy. Cancer-specific survival (CSS) overall (OS) compared among disease-related categories. parameters significantly correlated CSS used construct nomogram. multivariate analysis showed that stage OS. Overall, RT was improved for Stage T3-4 N1-3. subgroup N1-3 after surgery while chemotherapy indicated an without surgery. prognostic constructed had powerful discriminatory ability C-index CSS: 0.711. Conclusion Late-stage unfit need comprehensive treatment based node metastasis require adjuvant Generally, might improve late-stage patients. A reliable established can provide individual prediction SaC. Level evidence 3 Laryngoscope, 131:E489-E499, 2021.