Deep body composition phenotyping during weight cycling: relevance to metabolic efficiency and metabolic risk

摘要: Weight cycling may lead to adverse effects on metabolic efficiency (i.e. adaptive thermogenesis or 'metabolic slowing') and risks (e.g. increased risk for insulin resistance the syndrome). In order investigate these topics, partitioning of fat lean mass change in proportion both compartments) needs be extended organ tissue level because differs between adipose depots is metabolically heterogeneous being composed organs tissues differing rate. Contrary data obtained with severe weight loss regain people, most likely has no distribution obese patients. There even evidence an ability storage subcutaneous (at trunk men at limbs women) that provide a certain protection from ectopic lipid deposition thus explain preservation favourable profile despite regain. On other hand, mass-specific rate increase gain decrease mainly respective (and/or activity) active mass. Obese people could therefore have higher slope regression line resting energy expenditure (REE) fat-free leads overestimation when applied normalize REE after loss. Furthermore, addressing impact macronutrient composition diet mass, old controversy about whether calorie calorie, we discuss recent support low glycaemic maintenance countering challenge this concept by proposing opposite.