Myeloid-derived suppressor cells in lymphoma: The good, the bad and the ugly.
作者： A. Betsch , O. Rutgeerts , S. Fevery , B. Sprangers , G. Verhoef
DOI: 10.1016/J.BLRE.2018.04.006
关键词:
摘要: Lymphomas cause significant morbidity and mortality worldwide. A substantial number of patients ultimately relapse after standard treatment. However, the efficacy these therapies can be counteracted by patients' immune system, more specifically myeloid-derived suppressor cells (MDSC). MDSC are a heterogeneous group immature myeloid that suppress innate adaptive system via different mechanisms accumulate under pathological conditions, such as cancer. play role in induction progression cancer evasion. Increased numbers have been reported lymphoma subtypes associated with poor clinical outcome. This review aims to clarify their working mechanism subtypes. Furthermore, effect on immunotherapies will discussed.
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