Attenuation of penicillin models of epilepsy by nonsteroidal anti-inflammatory drugs
作者： Martin C Wallenstein
DOI: 10.1016/0014-4886(87)90080-X
关键词:
摘要: Abstract Prostaglandin and thromboxane levels increase in mammalian brain during seizures, but whether a metabolite of arachidonic acid has role induction, or is merely by-product, seizures still not clear. It been shown that nonsteroidal anti-inflammatory drugs block metabolism through inhibition the enzyme, cyclooxygenase. In present study, antiepileptic action antiinflammatory was investigated utilizing penicillin-induced focal (250 IU) primary generalized (2.5 million IU kg−1) models epilepsy. The effects on electrocortical motor manifestations both were examined. As group, significantly affected central nervous system excitation produced by penicillin. However, individual different parameters excitation. Paracetamol, most effective, delayed and/or blocked spikes models. Ibuprofen more effective against model. Mefenamic decreased number indomethacin voltage output together with earlier papers, suggests an plays induction several animal
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